We're more than happy to announce that our research paper entitled "Effect of intraocular pressure on crystalline lens oscillations: a computational study using porcine eye model" has been accepted for publication in PLoS One!

Abstract:

This study addresses a crucial knowledge gap by investigating the impact of intraocular pressure (IOP) on the wobbling characteristics of the crystalline lens in an ex vivo setting. It utilizes previous validated computational porcine eye models, which offer anatomical and physiological similarities to the human eye. These models incorporate fluid-structure interaction (FSI) to simulate the mechanical interaction between the fluids of the eye and the solid structures. Simulations were conducted under constant mechanical properties and boundary conditions, allowing for precise quantification of lens wobbling behavior with varying IOP levels. Various trends in lens displacement were observed at various IOP levels, revealing significant variations in both magnitude and duration. The results demonstrate the central role of intraocular pressure in influencing lens overshooting during rotational motion, with potential clinical implications. The observed lens displacement patterns, particularly in conditions like glaucoma, underscore the importance of considering IOP as a critical factor in understanding ocular biomechanics. Beyond immediate biomechanical relevance, the study's findings suggest the potential use of the Purkinje imaging system as a non-invasive method for IOP estimation based on lens overshoot as an "inverse solution" strategy. This non-invasive imaging technique offers a promising alternative to traditional methods, minimizing patient discomfort and potentially enhancing measurement precision.

The study is authored by Ali Dahaghin, Milad Salimibani, Agnieszka Boszczyk, Jorge Grasa, Damian Siedlecki.

Congratulations!

• Ali Dahaghin is an ESR in the OBERON project funded within the framework of the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 956720.
• Milad Salimibani, Agnieszka Boszczyk and Damian Siedlecki: grant number 2019/35/B/ST7/03998 (National Science Centre, Poland).
• FEM simulations have been carried out using resources provided by Wroclaw Centre for Networking and Supercomputing (http://wcss.pl), grant No. 556.