We have just received the final decision on acceptance of our study entitled "Assessment of Material Properties in Key Components of the Porcine Crystalline Lens During Overshooting" to be published in Acta of Bioengineering and Biomechanics!

Abstract:

Purpose: The porcine eye serves as a valuable surrogate for studying human ocular anatomy and physiology because of its close resemblance. This study focuses on the influence of material properties, specifically Young’s modulus and Poisson’s ratio, on the crystalline lens overshooting amplitude during rapid eye rotation. Methods: The finite element method (FEM) was employed to explore various material property scenarios, and sensitivity analysis was conducted to assess their impact on the mechanical displacement of the crystalline lens apex. The measurements were made of three output parameters: maximum displacement, time of maximum displacement appearance and stabilization time. Results: The results highlight the significance of fine-tuning of the zonule’s material properties, particularly Young’s modulus, in achieving a reliable model. They suggest that fine-tuning of these parameters can lead to a highly reliable model, enabling in-depth research in the opto-dynamic simulations. Conclusions: Having a complete examination of crystalline lens displacement in ex vivo porcine eye models and detailing crucial factors for accurate modeling will open the path for future studies especially in conditions affected by dynamic aspects of the crystalline lens or in in vivo research.

The study is authored by an international and multidisciplinary team of Milad Salimibani, Ali Dahaghin, Agnieszka Boszczyk, Jorge Grasa, Damian Siedlecki.

• Ali Dahaghin is an ESR in the OBERON project funded within the framework of the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 956720.
• Milad Salimibani, Agnieszka Boszczyk, Damian Siedlecki: grant number 2019/35/B/ST7/03998 (National Science Centre, Poland).
• FEM simulations have been carried out using resources provided by Wroclaw Centre for Networking and Supercomputing (http://wcss.pl), grant No. 556.